Abstract: DVM-system is designed for the development of parallel programs of scientific and technical calculations in the C-DVMH and Fortran-DVMH languages. These languages use a single DVMH-model of parallel programming model and are an extension of the standard C and Fortran languages with parallelism specifications in the form of compiler directives. The DVMH model makes it possible to create efficient parallel programs for heterogeneous computing clusters, in the nodes of which accelerators, graphic processors or Intel Xeon Phi coprocessors can be used as computing devices along with universal multi-core processors. The article describes the experience of the successful using of DVM-system to develop a parallel software code for calculating the problem of radiation magnetic gas dynamics and for research of plasma dynamics in the QSPA channel.